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The "no-DAC" variant lacks the drug affinity complex linker present on the longer-acting CJC-1295 with DAC, giving it a shorter functional duration that more closely matches natural GH pulse kinetics
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Additionally, it inhibits fatty acid synthase expression by activating the AMPK pathway, thus inhibiting fatty acid synthesis [188, 189]
Because DSIP primarily promotes slow-wave sleep, daytime drowsiness or grogginess can occur if the peptide disrupts normal sleep-wake patterns
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