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Accessed Jan 2020
Azuri J, Hammerman A, Aboalhasan E, Sluckis B, Arbel R
These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)
When GLP-1 binds to these receptors, it activates a cascade of intracellular signaling pathways that lead to a number of physiological effects
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