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Health Canada notes that GLP-1 drugs should only be sold by, and purchased from, licensed pharmacies, and that selling unauthorized or counterfeit products is illegal
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This multi-organ mechanism underlies efficacy across T2D, obesity, cardiovascular disease, and emerging indications (MASH, sleep apnea, neurodegeneration)
In clinical trials of injectable semaglutide and liraglutide, similar heart rate increases were observed but were not associated with adverse cardiovascular outcomes
In parallel, other researchers are exploring alternative models of use, such as starting with GLP-1 drugs for a short period to achieve initial weight loss, then switching to lifestyle programs, meal replacements or older medications for maintenance rather than keeping patients on GLP-1 drugs for the rest of their lives
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