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For those who have been on medication long-term and notice a slowdown, a semaglutide plateau or tirzepatide losing effectiveness can occur
But it is modest
Future of GLP-1 Medications: In Development: Oral formulations (Rybelsus exists but less effective) Monthly injection versions Triple agonist medications (GIP/GLP-1/glucagon) Combinations with other weight loss mechanisms The GLP-1 class will likely dominate weight loss treatment for the next decade while continuing to improve
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