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Armed with this information, your PlexusDx clinician can personalize your titration schedule rather than following a one-size-fits-all protocol

The Samaritans (116 123) provide 24/7 confidential support Your healthcare professional may: Conduct a thorough assessment using validated depression screening tools Review all your medications to identify potential interactions or contributors Consider whether symptoms might be related to Mounjaro, the underlying condition, or other factors Discuss whether continuing, adjusting, or temporarily pausing Mounjaro is appropriate Arrange blood tests to exclude other causes (thyroid dysfunction, vitamin deficiencies) Treatment options for depression may include: Psychological therapies such as cognitive behavioural therapy (CBT), available through NHS Talking Therapies services (self-referral possible in many areas via the NHS website) Antidepressant medication if clinically indicated, which can generally be used alongside Mounjaro, though monitoring may be needed as tirzepatide slows gastric emptying and could affect absorption of some oral medications Lifestyle interventions including structured physical activity, sleep hygiene, and social connection Referral to specialist mental health services if symptoms are severe or complex The decision about continuing Mounjaro should be individualised, weighing the benefits for diabetes control or weight management against any potential impact on mental wellbeing

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Clin Mol Hepatol 2024;30:649-652