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A 2014 study by Nakajima, Nagata, and colleagues published in Archives of Dermatological Research showed that reduced glutathione disrupts intracellular trafficking of tyrosinase to melanosomes, the rate-limiting enzyme in melanin synthesis, attenuating melanization at the cellular level
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"Depending on the intensity and duration of exercise, muscle ammonia may be elevated to the extent that it leaks (diffuses) from muscle to blood, and thereby can be carried to other organs." "It seems reasonable to assume that exhaustive exercise may induce a state of acute ammonia toxicity which, although transient and reversible relative to disease states, may be severe enough in critical regions of the CNS to affect continuing coordinated activity." "There have been numerous suggestions that elevated ammonia is associated with, or perhaps is responsible for, exercise fatigue...." "Since more is known about elevated brain ammonia during other diverse conditions such as disease states, chemically induced convulsion, and hyperbaric hyperoxia, some of these relevant data are discussed." J Cardiovasc Pharmacol
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