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Table 24a Severity scores 6 days post injections of subcutaneous tissue necrosis for histidine-buffered co-formulations Table 24b Severity scores 6 days post injections of subcutaneous tissue necrosis for citrate-buffered co-formulation vehicles Concluding Remarks The results presented in table 24a show that the type of tonicity agent included in the formulation affects its in vivo local tolerability