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Abbreviations DPP-4: Dipeptidyl peptidase-4 EMA: European Medicines Agency EPAC: Exchange protein directly activated by cAMP FDA: Food and Drug Administration FGF21: Fibroblast growth factor 21 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 PKA: Protein kinase A SGLT-2: Sodiumglucose cotransporter 2 References Moore B, Edie ES, Abram JS (1906) On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane