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Adipex and Suprenza (phentermine) Qsymia (phentermine-topiramate) Contrave (naltrexone-bupropion) Xenical and Alli (orlistat) Imcivree (setmalanotide) Plenity (carboxymethylcellulose hydrogel) Several additional agents are used off-label for weight loss at acceptable risk when prescribed thoughtfully and documented as off-label

There are two sides to that equation: energy intake and energy expenditure