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Your metabolism slows, but not as catastrophically as it would without medication
Additionally, efpeglenatide significantly improved blood sugar levels and lipid profiles
Defy Medical (2026) 4
In the phase 3 SLIMMER trial published in The Lancet Diabetes & Endocrinology last year, ecnoglutide achieved weight loss of 15.1% at 48 weeks, with no evidence of a plateauing of effect, along with improvements in waist circumference, blood pressure, lipid profile, HbA1c, fasting glucose, and insulin levels
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