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retatrutide remains in Phase 3 trials with expected 2027 approval Both medications share similar GI side effects, but retatrutide may have additional metabolic benefits from glucagon activation When comparing retatrutide vs tirzepatide , the fundamental difference lies in their receptor targets
C., Townsend, D
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(2022) "Tirzepatide Once Weekly for the Treatment of Obesity" The New England Journal of Medicine, 387(3) 3
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