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Although there is no evidence that PYY can directly influence insulin secretion in humans (53), activation of Y1 receptors is associated with increased intestinal motility and orexigenic effects, while conversely, Y2 receptor activation mediates the enterogastrone and anorectic effects of PYY (54)

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These discrepancies may arise from differences in sample sizes, study designs, and the power of individual datasets to detect genetic associations

Large CVOTs and other smaller studies have shown an association between the use of GLP-1RAs and DPP-4i on the relative rates of HF hospitalization