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Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, Rodriguez A (2022) Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial
While tirzepatide does not have a: Documented pharmacologic interaction with alcohol Combining them can increase side effects Undermine weight loss Present real risks for some people Many patients may tolerate occasional light drinking, but tolerance varies with dose, frequency of alcohol use, and underlying health conditions
The finding suggests that liraglutides cardiovascular benefits may be underappreciated, study populations and contexts matter (in higher-risk patients, differences in efficacy may be more pronounced), and/or that real-world effectiveness may differ from efficacy in selected trial populations, they say
Wegovy dosing follows a gradual escalation schedule over approximately five months, starting at 0.25 mg and increasing to a maintenance dose of 2.4 mg
