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Its active metabolite, retinoic acid, plays a crucial role in gene expression, influencing neuronal growth and differentiation
In any case, we think that the observed effect reflects a mechanism of action inherent to targeting the GLP-1 receptor. Braca said they decided to study the potential impact of GLP-1s on migraine based on previous work done by their research team, which suspected that a derangement in intracranial pressure control plays a role in the pathophysiology of migraine
However, excess iodine intake or a rise in intake following iodine fortification of an iodine-deficient population also gives an increased risk of thyroid autoimmunity, as attested by studies in many countries ( Reference Teng, Shan and Teng 14 Reference Aghini Lombardi, Fiore and Tonacchera 24 )
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