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It is this ratio, in particular, that distinguishes retatrutide from other triple agonists in development (such as survodutide, currently in Phase 3 trials at Boehringer)

Sainero-Alcolado, L., Liao-Pons, J., Ruiz-Prez, M

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However, additional data was gathered with the knockout mice that indicated that while AOD9604 did not lead to significant weight loss or increase in lipolysis without the beta(3)-adrenergic receptors, there was an increase in energy expenditure and fat oxidation