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John found that exenatide is an analog of human GLP-1RA, with 53% homology to human GLP-1RA

These include: Prediabetes High blood pressure High cholesterol Atherosclerotic cardiovascular disease Osteoarthritis Fatty liver disease Polycystic ovary syndrome (PCOS) Obstructive sleep apnea Inflammatory states Research is ongoing to better understand the potential benefits of GLP-1 medications for heart disease, kidney disease and inflammation-related conditions

Antizyme 2 is encoded by the OAZ2 gene

et al.) predicts a poor response to GLP-1 agonists precisely because the resistance lies downstream of both receptor classes