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for example, citrulline serves as a precursor for arginine synthesis and contributes to systemic nitrogen metabolism and nitric oxide signaling [98]

Side effects remain one of the primary drivers of discontinuation

McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis

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