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Despite its demonstrated efficacy and therapeutic promise, there is still uncertainty regarding its role in the metabolic regulation of PCOS, especially concerning the long-term effects on reproductive metabolic disorders

The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]

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Metformin doesn't have FDA approval for preventing cardiovascular events