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They play a role in the pathophysiology of the last of these by binding to their receptors in the brain to stimulate the release of cytokines, which lead directly to the formation of insoluble amyloid senile plaques and neuronal damage
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L-carnitine exerts hepatoprotective effects primarily through mitochondrial mechanisms
In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo
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