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Research has indicated that the -KG-consuming protein Tet3 (the primary -KG-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and then into 5-formyl- and 5-carboxy-dC) reroutes mitochondrial GDH, which converts glutamate into -KG in an NAD + -dependent manner, to the nucleus, indicating the onsite production of -KG
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Oral tirzepatide is taken once daily and dissolves under the tongue, while the injections are self-administered once a week
van Erven L, Schalij MJ (2010) Amiodarone: an effective antiarrhythmic drug with unusual side effects
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