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Maintaining mobility, staying well hydrated, and managing modifiable risk factors such as weight and smoking can help reduce overall thrombotic risk
One popular and practical solution has been the use of lipid-polymer hybrids pioneered by Zhang et al
doi:10.1345/aph.1M715
Comparisons With Other Diabetes Therapies Putting GLP1s in context with other antidiabetic agents offers additional insights: Thiazolidinediones (TZDs) are associated with increased fracture risk, especially in women SGLT2 inhibitors have raised concerns in some trials, particularly canagliflozin DPP-4 inhibitors appear largely neutral regarding skeletal effects Against this backdrop, GLP1s may have a neutral or possibly safer profile, though the data are not conclusive
