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In comparison, in neurotoxicity screening, in vitro human cell models have the advantages of high throughput, low cost, and cross-species applicability and are an effective alternative to in vivo experiments (Tian et al., 2020)

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The catch, again, is that the molecule needs to reach the dermal fibroblast layer to do any of this

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Lehrke M, Leiter LA, Hehnke U, Thiemann S, Bhandari A, Meinicke T, Johansen OE

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Centrally, it also influences dopaminergic and GABAergic neurotransmitter systems, which may contribute to its observed effects on stress-related tissue damage

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