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Chromophobe (Ch) renal cell carcinoma (ch-RCC or KICH) cells contain high levels of GSH and GSSG and exhibit higher sensitivity to ferroptotic inducers [295]

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The dominant role of the glutathione system over the thioredoxin system in mediating antioxidant electron flux in planta is consistent with our observations in yeast, and the concept of the ascorbate-glutathione cycle as the dominant route of NADP-dependent antioxidant electron flux in plants

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