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Clinicians should communicate the following to patients prescribed transdermal fentanyl patches 47 : Each new fentanyl patch should be applied to a different skin site after removal of the previous one The patch need not be applied to the area of discomfort or pain Patients may tape the edges of the patch with first aid tape If the patch falls off before 72 hours, dispose of it by folding it in half and flushing down the toilet Fentanyl patches must never be cut Never place a heating pad over a fentanyl patch Do not escalate fentanyl patch doses more frequently than every two to three days

Specifically, paired amplifications of oxidation and reduction currents is a characteristic signature of redox-cycling 24 and suggests that the melanins can participate in both oxidative and reductive redox-cycling by being switched to a reduced state (by accepting electrons from the mediators

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