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Most incretin weight-loss therapies are injected subcutaneously, but oral semaglutide is already licensed in the UK for T2DM as Rybelsus, while its manufacturer Novo Nordisk has published positive phase III results (OASIS-4, NCT05564117) for its 25mg semaglutide pill for weight loss 6

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When GLP-1R is activated, microglial activation is suppressed, reducing the levels of VEGF and other cytokines involved in neovascularization