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It participates in two critical enzymatic reactions: the conversion of methylmalonyl-CoA to succinyl-CoA (important for energy production) and the methylation of homocysteine to methionine (crucial for neurotransmitter synthesis and myelin maintenance)

In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure

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This combined approach permits larger amounts of drug to enter the brain parenchyma to accumulate and exert efficacy[176] (Fig