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Ozempic, while originally FDA-approved for managing type 2 diabetes, is now increasingly prescribed off-label for weight loss in patients without diabetes
Furthermore, it slightly reduced the increase of glucose transporter types 1 and 4 (GLUT1/4) during adipogenesis and led to a rise of GLP-1 mRNA, though protein levels remained unchanged
By leveraging real-world EHR data at scale, this research provides new evidence to inform both clinicians and policymakers as they weigh the role of GLP-1 RA therapy in cardiovascular care
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