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New England Journal of Medicine, 389(24), 22212232
The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction
Eating less does not always mean eating in a way that supports muscle, metabolism and long-term health
And so I concentrated on some cells in the gut that were producing a hormone that is called glucagon, which is also from the pancreas and is doing exactly the opposite as insulin normally
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