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For HLA-DR measurement a flow cytometry study on lymphocyte subpopulation was done using the ior dr1 (IgG2a) anti HLA class II fluorescent (FITC) monoclonal antibody

4.2 Stimuli-responsive nanoplatforms for spatiotemporal drug release The TME of osteosarcoma exhibits distinct physicochemical features, including acidic pH, elevated glutathione levels, and hypoxia, that can be exploited for stimuli-responsive drug release (45, 59)

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It has also been shown to protect brain tissue during acutestrokeand rescuememorydeficits following astroke