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Once anesthetized, the right knee joints of the animals were shaved, sterilized, and subjected to an intra-articular injection of collagenase type II
Oligodendrocytes and myelinated axons are sensitive to energy failure, glutamate excitotoxicity, and lipid peroxidation [1, 4, 9]
Without maintenance, the improvements will gradually diminish over time as natural collagen loss continues, but much of the structural rebuilding persists
In the meantime, todays peptide therapies are already helping many dogs enjoy greater mobility, comfort, and resilience
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