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This multi-receptor mechanism distinguishes it from existing licensed agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist)
Studies have shown that changes in gut microbiota composition can influence the brain via the vagus nerve, production of neurotransmitters such as serotonin, and systemic inflammation, contributing to both gastrointestinal symptoms and psychological comorbidities like anxiety and depression (Ullah et al., 2023)
The problem is that these were very small trials, sometimes containing only one or two patients and 25 patients at the most
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