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A double-blind, randomized, placebo-controlled trial demonstrated that perioperative high-dose intravenous injection of Gln (0.5 g/kg/day, P.O for 3 days) raised plasma Gln concentrations and maintained plasma GSH levels in postoperative patients undergoing cardiopulmonary bypass (CPB) [113]

In living cells, glutathione disulfide is reduced into two molecules of glutathione with reducing equivalents from the coenzyme NADPH