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The diagnosis of iron overload requires clinical correlation of the sign and symptoms with an estimation of total body iron accumulation/stores 2, 26, 27 In addition to a thorough clinical evaluation, all patients with suspected iron overload should have the following laboratory tests: a complete blood count (CBC) with RBC indices, routine iron studies and a metabolic panel including hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST])
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