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Grip strength increased by approximately 60% when the compound was combined with rigorous exercise training, compared to about 25% improvement from either exercise or treatment alone

Kwon and Park 2015 reported that intra-articular AOD-9604 injections, especially when combined with hyaluronic acid, improved cartilage scores and reduced lameness in a rabbit collagenase-induced osteoarthritis model

Claimed outcome NAD+ changes Evidence level Cell and animal evidence What research currently shows Blocking NNMT can preserve nicotinamide, a building block used to make NAD+

NNMT is an enzyme that works in your cells to manage energy and metabolism