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Stroke and Excitotoxicity Protection Excitotoxicity protection appeared in stroke models where bilateral carotid artery clamping produces ischemia-reperfusion injury with massive glutamate release

Dose adjustments have to be observed for the various DPP-4 inhibitors with renal elimination in dependence of the compound used and the severity of renal impairment (21, 22, 29, 32)

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These fluctuations directly contribute to the changes in serum metabolites and to cerebral metabolism that we have described here