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While freezing did not impact the concentrations of NAD + , NADH, GSH, or GSSG, it triggered the conversion of NADPH to NADP+, with about 508% of NADP + originating from oxidized NADPH (Supplementary Figure 1m-r)
Side effects, particularly gastrointestinal issues (62.6%), were the most frequently reported adverse events, consistent with both studie, which reported 65% and 63%, respectively [23, 27]
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