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At lower, sub-toxic concentrations, sulforaphane increased NRF2-mediated antioxidant defenses, ultimately enhancing neuronal survival in cell culture models driven by oxidative and inflammatory insults (Table 2) (Vauzour et al., 2010
GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)
Moreover, several investigators have found evidence of decreased activity of TPP-dependent enzymes, -ketoglutarate dehydrogenase and transketolase, in the brains of patients who died of AD (59)
Her liver was destroyed, and she ultimately died after a failed liver transplant
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