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Leveraging this unique requirement for Fsp1 in lung cancer, our studies demonstrate the therapeutic benefit of FSP1 inhibition in promoting ferroptosis and suppressing tumor growth and extending survival as a monotherapy in aggressive pre-clinical lung cancer models
Herein, we demonstrate that single particle cryo-EM can be applied to a member of the pyridine nucleotide-disulfide oxidoreductase protein family, which includes crucial drug targets for several human diseases
2014), suggesting that low GSH may be associated with particular symptoms of MDD
10.1104/pp.110.167569 74 FoyerC
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