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A 2025 systematic review (Vasireddi et al., SAGE Journals) confirmed this preclinical support but documented the absence of randomized controlled trials in humans

And although research on people without HIV is minimal to nonexistent at this time, researchers believe tesamorelin can yield similar outcomes in non-HIV populations.13 But if youre thinking its an alternative to a weight loss therapy like Ozempic, you should know that tesamorelin has demonstrated no effect on subcutaneous fat the fat that most people associate with overweight and obesity

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