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This rapid clearance may help prevent the toxic accumulation of mediators in the bloodstream, significantly reducing the severity and duration of systemic MCAS flares, such as flushing, gastrointestinal distress, and neurological inflammation

This evaluation ought to account for age, sex, family history, prior medical history, environmental exposures, and other established risk determinants that may increase the likelihood of occult malignancy

Immune checkpoint inhibitors might worsen autoimmune responses, further damage pituitary tissues, and further exhaust immune systems