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The strongest modifiable determinants of effect duration are: Accurate placement, at or near the motor end-plate - solid anatomical knowledge is paramount Appropriate dosage Correct patient selection

Binding affinity data from Hruby and colleagues' foundational work at Arizona (published through the 1990s and 2000s in the Journal of Medicinal Chemistry) established that MT2 has substantially greater potency than alpha-MSH across the receptor panel, with a particularly pronounced gain at MC4R relative to MC1R

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