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Technically, when the FDA first yanked tirzepatide off its shortage list in October 2024, both 503As and 503Bs could no longer legally make copycats (with one notable exception for the smaller 503As, who could still fill individual prescriptions if there was a medical reason the patient needed a slightly different version than the brand-name drugmore on this later)
It's recommended during periods requiring elevated Vitamin C dosage, such as during pregnancy, lactation, or intense physical labor
Affordable Care Act plans typically do not cover them
Studies show GLP-1 agonists can help reduce body weight in obese patients regardless if they have diabetes
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