Important safety considerations include a boxed warning for risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and risks of pancreatitis, gallbladder disease, acute kidney injury with dehydration, and diabetic retinopathy complications with semaglutide
B., Gonzalez, M
The segment is currently dominated by Eli Lilly's weight loss molecule Mounjaro (tirzepatide), which holds about 79% share, while Novo's semaglutide accounts for around 21% as of February-end
Dietary supplements, including green tea extract (particularly when standardized to have a high catechin concentration) and kava, black cohosh, high-dose curcumin, and some Chinese herbal preparations, are implicated in hepatocellular injury, cholestasis, or fulminant hepatic failure in both single case reports and small clinical series