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Clinical trials to determine whether treatment responses are driven directly by biological hallmarks of aging rather than by phenotypic classification In the absence of such evidence, SAGE-DM should be regarded as a biologically plausible theoretical framework that reinterprets diabetes among older adults principally as a disorder of declining insulin secretory capacity and limited metabolic flexibility, wherein insulin resistance is secondary or easing rather than the primary driving pathology of diabetes Limitations The present work has several important limitations that should be acknowledged

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Gastroenterology 135 (4), 13111321