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Female sex [2], obesity [3], and higher dermal nerve fiber regeneration [15] have been suggested as risk factors for painful DPN compared with painless DPN
Taking GLP-1 injections for non-obese individuals is still under research
They also highlight a recurring pattern in peptide drug development: early safety signals, particularly those observed at supraphysiologic exposure levels or in non-human models, have frequently led to premature abandonment of otherwise biologically compelling targets
Butler: Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors
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