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Contributing factors include reduced GHRH (stimulating hormone) secretion, increased somatostatin (inhibiting hormone) tone, changes in sleep architecture (less deep sleep), increased body fat (which suppresses GH), and decreased receptor sensitivity
Lancet Neurology
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Pregnant and lactating mothers are not advised to take semaglutide as it can increase the chances of birth defects in the foetus as well as miscarriages
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