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In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain

Additionally, these medications can have positive effects on conditions like sleep apnea and can contribute to overall health improvement in individuals with obesity

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It allows your gastrointestinal tract to acclimate without experiencing severe shock or severe nausea