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5g), but the growth rate was slightly different (optical density of controls at 72 h GLC/GAL = 1.6), given that galactose culture makes cells divide more slowly 47 , meaning that further controls are needed to confirm the role of mitochondrial metabolism in modulating sensitivity

JAMA 311(5):507-520

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Subsequent efforts to identify the enzyme responsible for cGAMP production led to the characterization of cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that directly binds double-stranded DNA and catalyzes cGAMP synthesis upon activation (Sun et al., 2013)