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In these experiments, GLP-1(2836) treatment increased glucose oxidation by 80% (383.5 48.3 vs
Dose Titration Table | Week | Tirzepatide Dose | |------|-----------------| | 1 to 4 | 2.5 mg weekly | | 5 to 8 | 5.0 mg weekly | | 9 to 12 | 7.5 mg weekly | | 13 to 16 | 10.0 mg weekly | | 17 to 20 | 12.5 mg weekly | | 21+ | 15.0 mg weekly (max) | Patients who cannot tolerate a dose increase may stay at the current dose for an additional 4 weeks before attempting the next step
Rushing titration or skipping steps increases the risk of significant nausea, vomiting, or other GI symptoms that may lead to treatment discontinuation
Banihani SA, Bayachou M, Alzoubi K
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