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Most of the weight lost in the first few days is water and glycogen not fat which is why progress appears fast at the beginning and then slows down
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Genes from the three or four most significantly enriched pathways from all comparisons were ranked according to P value (adjusted) and subsequently displayed on a heatmap with log(fold change) represented by colour
TRIUMPH-3 (NCT05882045) Design: Phase 3, 80-week, randomised, double-blind, placebo-controlled trial in adults with severe obesity (Class 2 or 3, BMI 35) and established cardiovascular disease, with or without type 2 diabetes
By weeks 48 at a stable dose, the majority of users adapt and symptoms either disappear or become consistently mild
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